Isotonic Regression Based-Method in Quantitative High-Throughput Screenings for Genotoxicity
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چکیده
منابع مشابه
Isotonic Regression Based-Method in Quantitative High-Throughput Screenings for Genotoxicity
Quantitative high-throughput screenings (qHTSs) for genotoxicity are conducted as part of comprehensive toxicology screening projects. The most widely used method is to compare the dose-response data of a wild-type and DNA repair gene knockout mutants, using model-fitting to the Hill equation (HE). However, this method performs poorly when the observed viability does not fit the equation well, ...
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ژورنال
عنوان ژورنال: Dose-Response
سال: 2014
ISSN: 1559-3258
DOI: 10.2203/dose-response.13-045.fujii